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Gaucher cells

Gaucher cells

Bone marrow histology (periodic acid Schiff stain, PAS) displaying macrophages on the left, with a cytoplasm resembling crinkled parchment. They are so-called 'Gaucher' cells. Gaucher's disease is characterised by a congenital defect of the enzyme glucocerebrosidase leading to an increase of certain glycolipids (cerebrosides) inside the macrophages. On the right side of the picture the bone marrow appears normal.