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Bone marrow histology of a patient with sarcoidosis

Bone marrow histology of a patient with sarcoidosis

Bone marrow histology (Giemsa stain) of a patient with sarcoidosis. This is a systemic disease of the connective tissue with granuloma formation and of unknown cause. However, a mutation in the BTNL2 gene greatly increases the risk of developing sarcoidosis. The granuloma consists of so-called 'epitheloid' cells, which derive from macrophages, and Langhans giant cells (not to be confused with Langerhans cells).