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Bone marrow cytology showing predominantly ringed sideroblasts

Bone marrow cytology showing predominantly ringed sideroblasts

This bone marrow cytology of a patient with MDS shows predominantly ringed sideroblasts in the Prussian Blue stain (iron stain). They are precursors of red blood cells, in which, due to a defect in iron utilisation, the iron is deposited in a ring-shaped distribution around the nucleus. Exact diagnosis: refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS).