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Malvern Zetasizer Nano ZS

  • Size measurement from 0,3nm (diameter) to 10 microns using patented NIBS (Non-Invasive Back Scatter) technology
  • Zeta potential using patented M3-PALS technology
  • Molecular weight measurement down to 980Da
  • Microrheology option to measure viscosity and viscoelasticity
  • Protein size measurement as dilute as 0.1mg/mL (Lysozyme)


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Performance, simplicity, versatility

The world's most widely used system. The Zetasizer Nano ZS is a high performance two angle particle and molecular size analyzer for the enhanced detection of aggregates and measurement of small or dilute samples, and samples at very low or high concentration using dynamic light scattering with ‘NIBS’ optics. The ZSP also incorporates a zeta potential analyzer that uses electrophoretic light scattering for particles, molecules and surfaces, and a molecular weight analyzer using static light scattering.Using Non-Invasive Backscatter optics (NIBS) it has significantly better performance than systems using 90 degree scattering optics. In addition, a microrheology option is available for measuring sample viscosity and viscoelastic properties, as well as a Protein Measurement option for protein mobility measurements. The flow mode option enables the system to be connected to an SEC or an FFF system to use as a detector for the size of proteins or nanoparticles. A choice of cuvettes are available, from disposable single-use to specific cells for viscous or high concentration samples or measuring the zeta potential of surfaces.

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Measurement range
0.3nm - 10.0 microns* (diameter)

Measurement principle
Dynamic Light Scattering

Minimum sample volume

Better than +/-2% on NIST traceable latex standards

Better than +/-2% on NIST traceable latex standards

0.1mg/mL (Lysozyme)

Measurement range
3.8nm - 100 microns (diameter)

Measurement principle
Electrophoretic Light Scattering

Minimum sample volume
150µL (20µL using diffusion barrier method)

0.12µ for aqueous systems using NIST SRM1980 standard reference material

10mg/mL (BSA).

Measurement range
980Da - 20M Da*

Measurement principle
Static Light Scattering using Debye plot

Minimum sample volume
12µL (3-5 sample concentrations required)

+/- 10% typical

Measurement principle
Dynamic Light Scattering

Minimum sample volume
12µL (DLS measurement only) *maximum range, sample dependent

Temperature control range
0°C - 90°C +/-0.1**, 120ºC option

Light source
He-Ne laser 633nm, Max 4mW.

Laser safety
Class 1

320 (W) x 600 (D) x 260 (H) mm

21 kg

How it works

How it works

The Zetasizer Nano ZS incorporates three techniques in a single compact unit, and has a range of options and accessories to optimize and simplify the measurement of different sample types.

Dynamic Light Scattering is used to measure particle and molecule size. This technique measures the diffusion of particles moving under Brownian motion, and converts this to size and a size distribution using the Stokes-Einstein relationship. Non-Invasive Back Scatter technology (NIBS) is incorporated to give the highest sensitivity simultaneously with the highest size and concentration range.

Measurement of size as a function of concentration enables the calculation of kD, the DLS interaction parameter.

The Microrheology option uses the DLS measurement of tracer particles to probe the structure of dilute polymer and protein solutions.

Laser Doppler Micro-electrophoresis is used to measure zeta potential. An electric field is applied to a solution of molecules or a dispersion of particles, which then move with a velocity related to their zeta potential. This velocity is measured using a patented laser interferometric technique called M3-PALS (Phase analysis Light Scattering). This enables the calculation of electrophoretic mobility, and from this the zeta potential and zeta potential distribution.

A surface zeta potential accessory uses tracer particles to measure electro-osmosis close to a sample surface to calculate the zeta potential of the surface.

Static Light Scattering is used to determine the molecular weight of proteins and polymers. In this technique, the scattering intensity of a number of concentrations of the sample is measured, and used to construct a Debye plot. From this the average molecular weight and second virial coefficient can be calculated, which gives a measure of molecule solubility.

This technique is very demanding on the sensitivity and stability of the whole system, and requires that every element of the design is optimized to ensure accuracy and repeatability.

The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place for confirmation of data quality, and an expert advice system is provided to assist with data interpretation.

The MPT-2 Autotitrator enables the study of the effect of changes in pH, conductivity, or any additive to be automated.

A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume, concentration and flow measurement.

Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a viscometer to determine the sample viscosity to the accuracy required for the techniques used.



The Zetasizer NanoSampler is a sample delivery system that ensures highly precise and reproducible automated loading of samples into your Zetasizer Nano. The NanoSampler adds automation and unattended operation in a versatile, compact package, maximising the productivity of your Zetasizer Nano. While the benefits of automated operation are useful for all users, the NanoSampler is ideally suited for laboratories where a large number of measurements are required and reproducibility or multi-variate studies are important.

MPT-2 Autotitrator
A cost effective accessory designed to automate the measurement of size and zeta potential as a function of pH, conductivity or any soluble additive.SV-10 viscometerThe SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.

Disposable folded capillary cell (DTS1070)
The zeta potential of colloids and molecules is extremely sensitive to contamination from components of a previous sample used in a measurement cell. The use of a disposable cell completely eliminates this potential contamination issue.The folded capillary cell provides the benefits of the accuracy of measurement of a capillary cell with the ease of use of a disposable cell.Although, disposable, including the electrodes, for low conductivity samples each cell can be used for hundreds of measurements if required.The cell can be used with the autotitrator, where multiple measurements are routinely done over a wide pH range.

Universal 'dip' cell kit
The dip cell is used for the measurement of zeta potential of samples in aqueous and non-aqueous dispersants, and is designed to be cleaned and reused. It is for batch measurements using standard polystyrene or glass cuvettes.

High concentration zeta potential cell kit
The high concentration cell enables the measurement of the zeta potential of samples with little or no dilution in any Zetasizer Nano system that measures zeta potential.The cell has a flow configuration so can be used for stop-flow size and zeta potential measurements using an MPT-2 autotitrator as well as batch measurements.

Surface zeta potential accessory
The characterization of surfaces and interfaces is critical in a wide range of industries including consumer products, specialty chemicals, pharmaceuticals and life sciences. In each of these application areas, the interaction of molecules and particles with surfaces can influence the material properties of the end product.The surface zeta potential accessory enables the measurement of the zeta potential of flat surfaces such as filter paper, silica, polymers and bone, using a standard Zetasizer Nano system.

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