Sysmex Nederland

Malvern Zetasizer Nano S90

  • Size measurement from 0,3nm (diameter) to 5 microns using 90 degree scattering optics
  • Molecular weight measurement down to 9.800Da
  • Automation of measurements using an autotitrator option
  • Alternative laser, 50mW at 532nm for samples incompatible with the standard 633nm laser fitted
  • Systems can be upgraded to add zeta potential at a later date


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Malvern Zetasizer Nano S90

An entry level system for the measurement of particle and molecular size at a 90 degree scattering angle using Dynamic Light Scattering, and molecular weight using Static Light Scattering. The Zetasizer Nano S90 is the perfect lower cost solution when the ultimate in sizing sensitivity is not necessary, or where identical results to a legacy system with 90 degree scattering optics are required.

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Measurement range

0.3nm - 5.0 microns* (diameter)

Measurement principle
Dynamic Light Scattering

Minimum sample volume

Better than +/-2% on NIST traceable latex standards

Better than +/-2% on NIST traceable latex standards

10mg/mL (Lysozyme)

Measurement range
Molecular weight

Measurement principle
Static Light Scattering using Debye plot

Minimum sample volume
20µL (3-5 sample concentrations required)

+/- 10% typical

Temperature control range
0°C - 90°C +/-0.1**, 120°C option

Light source
He-Ne laser 633nm, Max 4mW.

Laser safety
Class 1

320 (W) x 600 (D) x 260 (H) mm

21 kg

How it works

How it works

The Zetasizer Nano S90 incorporates 2 techniques in a single compact unit, and has a range of options and accessories to optimize and simplify the measurement of different sample types.

Dynamic Light Scattering is used to measure particle size and molecule size. This technique measures the diffusion of particles moving under Brownian motion, and converts this to size and a size distribution using the Stokes-Einstein relationship. Non-Invasive Back Scatter technology (NIBS) is incorporated to give the highest sensitivity simultaneously with the highest dynamic size and concentration range.

Static Light Scattering is used to determine the molecular weight of proteins and polymers. In this technique, the scattering intensity of a number of concentrations of the sample is measured, and used to construct a Debye plot. From this the average molecular weight and second virial coefficient can be calculated.
This measurement is very demanding on the sensitivity and stability of the whole system, and means that every element of the design has been optimised to ensure accuracy and repeatability

The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place to look for the success of a measurement, and expert advice is given to assist with data interpretation.

The MPT-2 Autotitrator enables the study the effect of changes in pH, conductivity, or any additive to be automated.
A range of disposable and reusable cells are available to optimise the measurement in terms of sample volume, concentration and for flow measurement.

Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a viscometer to determine the sample viscosity to the accuracy required for the techniques used.



The Zetasizer NanoSampler is a sample delivery system that ensures highly precise and reproducible automated loading of samples into your Zetasizer Nano. The NanoSampler adds automation and unattended operation in a versatile, compact package, maximising the productivity of your Zetasizer Nano. While the benefits of automated operation are useful for all users, the NanoSampler is ideally suited for laboratories where a large number of measurements are required and reproducibility or multi-variate studies are important.

A cost effective accessory designed to automate the measurement of size and zeta potential as a function of pH, conductivity or any soluble additive.SV-10 viscometerThe SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.

Quartz flow cell (ZEN0023)
Add flow capability for size measurements to the Zetasizer.

12mm Glass cell (PCS1115)
Glass cuvette for use with the dip cell.

12mm Square Polystyrene Cuvettes (DTS0012)
Disposable polystyrene cuvettes.

12mm square glass cell (PCS8501)
Glass cuvette for batch measurements.

Disposable Solvent Resistant Micro Cuvette (ZEN0040)
Disposable plastic micro cuvette, for size measurement at 173° (NIBS) optics only.

Low-volume quartz batch cuvette (ZEN2112)
Low-volume quartz batch cuvette for size and molecular weight measurements.

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