FIT screening

The FIT-based screening test is easy and therefore manages to attract high participation rates – the main driver behind the success of any national or regional screening programme. Generally, national or regional administrations assume responsibility for managing the logistics, financials and efficiency of the programme in close cooperation with their selected laboratory partners.

For further information, you can check our FIT for screening microsite. 
www.fitscreening.eu/

 

 

Sysmex Blood Film Master RAL-Stainer

Blood Film Master Advanced

  • Methanol-free staining
  • Standardised blood films and stained blood smears
  • Ideal for manual differential and automated digital morphology
  • Easy to use
  • Safe

From smear production to smear staining

The Blood Film Master Advanced is a bundle of two top products: our hemoslider and the automated RAL Stainer, which uses the excellent MCDh reagents.

Blood film preparation and staining are simple procedures that can fail or be less effective than they could be. Our Blood Film Master Advanced eliminates this issue by providing a system of standardised, easy and safe staining. Proper blood film and stain preparation are rewarded later when blood films are analysed on automated digital morphology systems or viewed under the microscope. You set the stage for ensuring patients’ analysis results can be of the highest quality.

The Blood Film Master Advanced concept addresses the three areas of blood film preparation that can cause issues. The Hemoslider produces consistently high quality films. Blood staining occurs in the automated RAL Stainer using methanol-free MCDh reagents. The resulting blood films are well spread, well stained and of excellent contrast and quality.

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Specifications

Specifications

HemoSlider Set
Size HemoSlider    12 * 4 * 3 cm
Weight    150 g
Spreader Blades    10 Blades included in the Set

MCDh Reagents
MCDh reagent Kit    Ready to use on RAL Stainer
Stain capacity    Maximum 500 slides
Shelf Life    18 months unopened
21 days after opening
Storage Temperature    15 to 30°C

RAL Stainer
RAL Stainer    Staining of whole blood smears
Staining of bone morrow smears

Throughput
Depending on the used staining protocol.

Standard stain protocol: 11 min
Drying cycle: 5 minutes
Staining baths    4 staining and 1 rinsing bath
Loading capacity    Up to 10 slides per basket
2 loading stations

Dimensions RAL Stainer
Height: 62.4 cm
Diameter: 42.5 cm
Weight: 28 kg
Supported Stain: MCDh reagent Kit (Methanol free)
Maintenance: No reagent priming
Not cleaning

HemoSlider

HemoSlider

  • Constant blood smear quality
  • Easy to use
  • Small, strong metal design
  • Easy to clean
  • Autoclave resistant

The wedge slide, or push-slide technique developed by Maxwell Wintrobe, is the standard method for preparing peripheral blood films. It is also the method used by the HemoSlider.

The HemoSlider produces consistently high quality blood smears. And it is easy to use. Semi-automatic, it ensures blood cells are evenly distributed on the smear with a single action. The reproducible results and standardised quality makes it simple even for technicians with less experience. Because the smears are standardised, you will find it significantly easier to compare the blood cells so that morphological assessment is also easier. For an ideal workflow, you should also use a standardised staining process.

MCDh Reagents

MCDh Reagents

  • Ready to use:   
  • Methanol-free, polyvalent
  • Short staining protocol
  • Clean and easily rinsed
  • Digital quality   

MCDh (Micro Chromatic Detection haematology) is a panoptic haematology staining method. It is methanol-free and consists of a sequence of four specific reagents for staining peripheral blood and/or bone marrow smears in the haematology laboratory.

The chemical properties of each reagent gradually reveal blood or marrow elements during the staining process. So does the appearance of a purple coloration (Romanowsky-Giemsa type effect), notably on chromatin, platelets and neutrophilic granules.

The reagents deliver superb stains in line with standardisation trends in diagnostics techniques. Importantly, the staining time is almost 50% shorter compared to the standard May Grünwald – Giemsa staining method for manual blood film staining. This means you can save significant amounts of time, especially if you have larger volumes of stains.

Using the RAL stainer, the four reagents are used one after the other, and always in the correct order. The MCDh reagents are ready to use – which means you no longer have to do any mixing - and deliver stains of standardised, reproducible quality. This is further enhanced by the limited number of manual processes. It sets the stage perfectly for the next step – digital morphology.

Four components for standardised stains

The MCDh reagents kit consists of four components that are matched in terms of volume and composition. Since they are ready to use, this eliminates the time needed for mixing and delivering specific concentrations.  You simply load them into the RAL Stainer. It also reduces the material you have to use as there is no need for containers or buffer solutions for dilution.

The process is much simpler than regular procedures as there are far fewer steps involved. This has a knock-on effect as it reduces documentation (SOPs, QMS manual) and delivers smoother workflows that are easier to follow for staff and QMS auditors alike.

Thanks to fewer manual interventions, you reduce potential errors and produce stains of uniform staining quality. As a result, you will find it easier to compare differentiation results.

Staining mechanism

MCDh 1

This is a blend of neutral stains used to fix smears and to prepare staining mainly of water-soluble elements (basophilic granules). These stains are not active in alcohol media and only act selectively when they are released into buffered aqueous solution.

 

MCDh 2

This reagent leads to concentration and precipitation of the stain on the erythrocytes, neutrophilic granular of the cytoplasm and on eosinophilic granules.

MCDh 3

Is used for staining the monocyte and lymphocyte cytoplasm, and performs the red metachromatic staining of azure granules.

MCDh 4

Is a rinse that removes excess stain from the cells and finalises the staining.

RAL Stainer

RAL Stainer

  • Ready to use MCDh reagents kit for direct loading
  • No hazardous exposure
  • No hazardous handling
  • Low reagent consumption
  • No routine maintenance needed

Once you have produced a great blood film, you want a great stain. If you want to ensure you produce consistently high quality levels and standardisation, we recommend the RAL Stainer. It is a compact, simple, intelligent and safe automated staining system for staining whole blood smears that is used in combination with our methanol-free MCDh staining reagents. It also reduces staining time by almost half compared to standard methods.   

Another huge advantage of the RAL Stainer is that your lab staff can get on with other tasks with confidence, even when the staining process is running. You don’t have to worry about staining intervals are being observed – the RAL Stainer does so automatically.

The ready-to-use methanol-free MCDh reagents come in closed cartridges, which extends their lifespan and eliminates the possibility of contamination. And RFID tags prevent reagents being used beyond their expiry dates – further reducing the potential for errors. After loading the MCDh cartridges, the stainer is ready for use. You don’t have to prime or stain the reagents and can create user-defined protocols for bone marrow, malaria screening, etc.

Fast staining

One of the reasons the stainer is so fast is that you can load up to 10 slides into a slide holder, which is then placed in one of the two loading drawers. Press the start button and the slide holder is dipped in each of the 5 staining stations. The standard MCDh staining protocol has been optimised for peripheral blood smears, which are stained within 15 minutes. Because it has two loading drawers, loading and unloading is continuous. And while the staining process is going on, your technicians can confidently get on with other tasks.

Maintenance-free and safe

One of the major time-consumers in staining is maintenance. You will be glad to hear the stainer needs none. And your staff are entirely safe as well, as the staining is performed in a completely closed system – an active carbon filter neutralises reagent vapours.  

Key benefits

 

Simple:

Ready to use MCDh reagents Kit for direct loading

No priming of staining reagents required

Customisable staining protocols

 

Safe:

Reliable and robust mechanism

No hazardous exposure

No hazardous handling

Activated carbon filter neutralises reagent vapours

Automatic draining of expired reagents

 

Intelligent:

RFID (Radio Frequency IDentification):

  • Automatic detection and management of reagents kit
  • Traceability of stain cycle performance

    Detects rinsing and effluent liquid levels

 

Efficient:

Low reagent consumption

No routine maintenance needed

Standardised and repeatable staining protocols

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