FIT screening

Dikkedarmkanker, ook wel colorectaal carcinoom, is een veelvoorkomende ziekte onder voornamelijk ouderen. Het detecteren van dikke darmkanker in een vroeg stadium kan de overlevingskans van een patiënt aanzienlijk vergroten. Door gebruik te maken van een fecale immunochemische test (FIT) worden kleine hoeveelheden bloed (met behulp van antilichamen voor humaan hemoglobine) opgespoord in ontlastingsmonsters.


Sysmex biedt FIT-tests aan voor twee hoofdgroepen: grootschalig tests voor nationale of regionale bevolkingsonderzoeken, en symptomatische tests die hoofdzakelijk plaatsvinden in ziekenhuizen of klinische omgevingen. Lees hier meer over op onze FIT screening microsite www.fitscreening.eu/

  • GROWING YOUR KNOWLEDGE
    GROWING YOUR KNOWLEDGE
  • DEVELOPING YOUR SKILLS
    DEVELOPING YOUR SKILLS
  • HARVESTING EXPERTISE
    HARVESTING EXPERTISE

Percentage of hypo-haemoglobinised red cells (HYPO-He) and hyper-haemoglobinised red cells (HYPER-He)

What are HYPO-He and HYPER-He used for?

Together with other parameters, HYPO-He is used in RBC indices to distinguish between iron defiency anaemia and thalassaemia.

The use of HYPO-He as well as MicroR is recommended in nephrology guidelines such as the European Best Practice Guidelines (EBPG), National Kidney Foundation Kidney Disease Outcome Quality Initiative (NKF KDOQI).

How are HYPO-He and HYPER-He determined?

HYPO-He and HYPER-He are parameters analysed in the reticulocyte (RET) channel. They are derived from the haemoglobin content of all mature RBC (RBC-He), which can be calculated based on the high-angle forward scatter (FSC). The FSC signal is converted into picograms (pg) using a proprietary algorithm and in healthy individuals the resulting RBC-He value is comparable to the mean corpuscular haemoglobin (MCH) value. Subsequently, this RBC-He value is used to determine HYPO-He and HYPER-He.

HYPO-He is the percentage of RBC with cellular haemoglobin content lower than 17 pg, whereas HYPER-He is the percentage of RBC with cellular haemoglobin content higher than 49 pg.

 

 

Figure: each cell is plotted in the RET scattergram based on its fluorescence intensity (x-axis) and its high-angle forward-scattered light signal (y-axis), which reflects characteristics of both cell size and cellular content. The left panel shows a sample from a healthy individual with HYPO-He less than 1% and the right panel shows a sample with HYPO-He more than 60%

HYPO-He and HYPER-He are diagnostic parameters on XN-Class analysers that have the RET channel. *

 

*In the XT-4000i and XE-5000 analysers these are research parameters that are derived from the RET channel and named %HYPO-He and %HYPER-He. Research parameters should not be used for in vitro diagnostics.

Immature Granulocyte
(IG)

Immature Platelet Fraction
(IPF# and %)

Nucleated Red Blood Cells
(NRBC)

Reticulocyte haemoglobin
equivalent (RET-He)

Neutrophil Granularity
and Reactivity
(NEUT-GI, NEUT-RI)

Microcytic and Macrocytic
Red Blood Cells
(MicroR, MacroR)

Fragmented
red blood cells (FRC*)

Reactive and Antibody-
synthesizing Lymphocytes
(RE-LYMP, AS-LYMP)

Our Glossary

An alphabetical listing of scientific terms

Explore our Glossary

Peer-reviewed literature list

Enjoy our Media Centre
All
  • All
  • Documents
  • Podcast
  • Beelden
  • Video's
See our library of smears https://www.sysmex.nl/library/image-gallery.html
Learn more about our concept https://www.sysmex.nl/onderneming/who-is-sysmex/silent-design.html
Growing your knowledge Visit our Academy
Sysmex XN – TAILORING YOUR HAEMATOLOGY See the scalability of XN http://www.sysmex.nl/media-center/xn-tailoring-your-haematology-13880.html
See our library of smears https://www.sysmex.nl/library/image-gallery.html
Growing your knowledge Visit our Academy
Sysmex XN – TAILORING YOUR HAEMATOLOGY See the scalability of XN http://www.sysmex.nl/media-center/xn-tailoring-your-haematology-13880.html