FIT screening

Dikkedarmkanker, ook wel colorectaal carcinoom, is een veelvoorkomende ziekte onder voornamelijk ouderen. Het detecteren van dikke darmkanker in een vroeg stadium kan de overlevingskans van een patiënt aanzienlijk vergroten. Door gebruik te maken van een fecale immunochemische test (FIT) worden kleine hoeveelheden bloed (met behulp van antilichamen voor humaan hemoglobine) opgespoord in ontlastingsmonsters.


Sysmex biedt FIT-tests aan voor twee hoofdgroepen: grootschalig tests voor nationale of regionale bevolkingsonderzoeken, en symptomatische tests die hoofdzakelijk plaatsvinden in ziekenhuizen of klinische omgevingen. Lees hier meer over op onze FIT screening microsite http://www.fitscreening.eu/

Malvern Panalytical Bioscience Days

Datum: 2018/05/15 - 2018/05/16

Locatie: Etten-Leur

Additional info: Sysmex Office

Address: Ecustraat 11

Land: The Netherlands

We are pleased to invite you to our free of charge Malvern Panalytical Bioscience Days on the 15th and 16th of May 2018 at our freshly renovated office and demonstration laboratory in Etten-Leur (NL).

This day meeting will give participants an overview of the uniques features of Malvern Panalyticals technology in the Bioscience field through biophysical characterization. These biophysical characterization underpins research and development activities aimed at deciphering complex biological systems - from elucidating molecular interactions and cellular processes to developing more effective drugs and vaccines. During this day there will be prominent speakers and demonstration sessions.

Date: Tuesday the 15th and Wednesday the 16th May
Time: both days from 9:00 am - 5:00 pm followed by closing drinks
Location: Sysmex, Ecustraat 11, 4879NP in Etten-Leur (NL)

You can easily register by clicking here.

Program

Tuesday 15 May
09:00 - 09:30 | Registration and coffee/tea
09:30 - 09:45 | Introduction Sysmex/Malvern - Bruno Devisscher (Sysmex)
09:45 - 10:45 | Orthogonal particle characterization techniques for bio-applications:an introduction to DLS (Dynamic Light Scattering), NTA (Nanoparticle Tracking Analysis) and RMM (Resonant Mass Measurement) - Markus Epe/Roberto Ghiandoni (Malvern Panalytical)
Particle size is an important parameter for those interested in the characterization of nanoscale materials. The general concern for many researchers using particle measurement instrumentation is how can I trust my data? Is the data affected in any way by the technology employed, or alternatively by the user themselves through sample preparation/analysis parameters? To answer this question, we need to consider the use of an independent and orthogonal measurement modality in order to provide measurement validation.This presentation will cover the principles of Dynamic Light Scattering (DLS), Nanoparticle Tracking Analysis (NTA) and Resonant Mass Measurement (RMM). As well as describing how these technologies can be used in conjunction to provide a comprehensive and powerful measurement suite. Application examples will include sub visible particles in injectables.
10:45 - 11:15 | ITC / DSC Characterization of the interactions of biomolecules and determination of thermal stability - Patrick King (Malvern Panalytical)
Higher-order biomolecular structures and their dynamic interactions with various ligands drive and regulate all biological processes; studies of biomolecular changes are fundamentally important in all areas of life sciences. Isothermal titration calorimetry (ITC) and Differential Scanning Calorimetry (DSC) provide a rigorous understanding and quantification of the thermodynamic and kinetic properties of these changes (for example, free to bound state in a biomolecular interaction or folded to unfolded estate of a biomolecule). Both, ITC and DSC are the ideal techniques for the measurement of biological binding interactions and biomolecular stability since the data provided does not rely on the presence of chromophores or fluorophores, nor requires labelling of the sample. ITC and DSC rely only on the detection of a heat change associated with the studied system of interest, enabling scientists in academia and industry to better understand the conformational stability of their biomolecules and their binding to biologically relevant interactants. This presentation will cover the principles of ITC and DSC and it exemplifies a broad range of applications enabled by the direct nature of the technique. A special focus will be given to the benefits of PEAQ-ITC and PEAQ-DSC, the latest generation of MicroCal microcalorimeters, and the solutions it offers for addressing current bottlenecks associated with the interaction analysis and/or biomolecular stability.
11:15 - 11:30 | Coffee break
11:30 - 12:00 | Thermodynamic dissection of the cooperativity of a cytokine-receptor assembly - Guest speaker: Erwin Pannecoucke (VIB, Vlaams Instituut voor Biotechnologie)
12:00 - 13:00 | Parallel practical sessions MicroCal, NS300 NTA with new Sample Assistant - Patrick King / Roberto Ghiandoni (Malvern Panalytical)
13:00 - 13:45 | Lunch sponsored by Sysmex
13:45 - 14:15 | OMNISEC: Advanced detectors for chromatography - Additional insights into biomolecular stability and aggregation - John Stenson (Malvern Panalytical)
Size Exclusion Chromatography (SEC), is a very popular analytical technique for studying protein molecular weight, oligomeric state, and aggregation. Multi-detector SEC combines SEC with advanced detectors such as light scattering (RALS/LALS or MALS) and an intrinsic viscometer (IV). While the more conventional detectors such as refractive index (RI) and ultraviolet (UV) give concentration information, the addition of light scattering and intrinsic viscosity enable further characterization of protein absolute molecular weight and structure, respectively. Importantly in a multi-detection system the molecular weight is no longer relative to any protein standards but an absolute measurement.This presentation will discuss how these measurements can be applied. Application examples will include oligomeric and aggregation state of proteins such as immunoglobulins; conformational changes in intrinsically disordered proteins; and compositional measurements of protein conjugates such as PEGylated proteins and membrane proteins.
14:15 - 14:40 | Taylor-Dispersion Analysis (Viscosizer TD) for biophysical characterization of molecules - Markus Epe (Malvern Panalytical)
Viscosizer TD is a biophysical characterization tool that provides unique measurement capabilities for researchers assessing conformational stability, self-association (kD) and solubility of large variety of molecules from small synthetic compounds to target biomolecules in complex solutions. Microcapillary flow methodology also allows complementary relative viscosity measurement, providing high resolution measurements with high reproducibility at low concentration and low viscosity.
14:40 - 15:15 | Introducing Morphologically Directed Raman Spectroscopy for Biopharmaceutical Applications - Anne Virden / Robert Taylor (Malvern Panalytical)
Measuring the size and chemical identity of particles in biotherapeutic formulations is extremely important to ensuring their efficacy and safety.Morphologically Directed Raman Spectroscopy is a unique combination of automated image analysis and RamanSpectroscopy.We will show how this technology can be used to link particle images with Raman spectra to measure particle size and shape, as well as identifying whether particles are protein aggregates, silicon oil or other contaminants.

15:15 - 15:30 | Coffee break
15:30 - 16:00 | Exciting Zetasizer news; MADLS, adaptive correlation, particle concentration - Patrick King (Malvern Panalytical)
16:00 - 17:00 | Parallel practical sessions Zetasizer, new Morphologi4ID - Patrick King / Anne Virden / Robert Taylor (Malvern Panalytical)
17:00 - ... | Closing & drinks - Bruno Devisscher (Sysmex)

Wednesday 16 May
09:00 - 09:30 | Registration and coffee/tea
09:30 - 09:45 | Introduction Sysmex/Malvern - Bruno Devisscher (Sysmex)
09:45 - 10:45 | Orthogonal particle characterization techniques for bio-applications:an introduction to DLS (Dynamic Light Scattering), NTA (Nanoparticle Tracking Analysis) and RMM (Resonant Mass Measurement) - Markus Epe/Roberto Ghiandoni (Malvern Panalytical)
Particle size is an important parameter for those interested in the characterization of nanoscale materials. The general concern for many researchers using particle measurement instrumentation is how can I trust my data? Is the data affected in any way by the technology employed, or alternatively by the user themselves through sample preparation/analysis parameters? To answer this question, we need to consider the use of an independent and orthogonal measurement modality in order to provide measurement validation.This presentation will cover the principles of Dynamic Light Scattering (DLS), Nanoparticle Tracking Analysis (NTA) and Resonant Mass Measurement (RMM). As well as describing how these technologies can be used in conjunction to provide a comprehensive and powerful measurement suite. Application examples will include sub visible particles in injectables.
10:45 - 11:00 | Coffee break
11:00 - 11:30 | ITC / DSC Characterization of the interactions of biomolecules and determination of thermal stability - Patrick King (Malvern Panalytical)
Higher-order biomolecular structures and their dynamic interactions with various ligands drive and regulate all biological processes; studies of biomolecular changes are fundamentally important in all areas of life sciences. Isothermal titration calorimetry (ITC) and Differential Scanning Calorimetry (DSC) provide a rigorous understanding and quantification of the thermodynamic and kinetic properties of these changes (for example, free to bound state in a biomolecular interaction or folded to unfolded estate of a biomolecule). Both, ITC and DSC are the ideal techniques for the measurement of biological binding interactions and biomolecular stability since the data provided does not rely on the presence of chromophores or fluorophores, nor requires labelling of the sample. ITC and DSC rely only on the detection of a heat change associated with the studied system of interest, enabling scientists in academia and industry to better understand the conformational stability of their biomolecules and their binding to biologically relevant interactants. This presentation will cover the principles of ITC and DSC and it exemplifies a broad range of applications enabled by the direct nature of the technique. A special focus will be given to the benefits of PEAQ-ITC and PEAQ-DSC, the latest generation of MicroCal microcalorimeters, and the solutions it offers for addressing current bottlenecks associated with the interaction analysis and/or biomolecular stability.
11:30 - 12:30 | Parallel practical sessions MicroCal, NS300 NTA with new Sample Assistant - Patrick King / Roberto Ghiandoni (Malvern Panalytical)
12:30 - 13:15 | Lunch sponsored by Sysmex
13:15 - 13:45 | OMNISEC: Advanced detectors for chromatography - Additional insights into biomolecular stability and aggregation - John Stenson (Malvern Panalytical)
Size Exclusion Chromatography (SEC), is a very popular analytical technique for studying protein molecular weight, oligomeric state, and aggregation. Multi-detector SEC combines SEC with advanced detectors such as light scattering (RALS/LALS or MALS) and an intrinsic viscometer (IV). While the more conventional detectors such as refractive index (RI) and ultraviolet (UV) give concentration information, the addition of light scattering and intrinsic viscosity enable further characterization of protein absolute molecular weight and structure, respectively. Importantly in a multi-detection system the molecular weight is no longer relative to any protein standards but an absolute measurement.This presentation will discuss how these measurements can be applied. Application examples will include oligomeric and aggregation state of proteins such as immunoglobulins; conformational changes in intrinsically disordered proteins; and compositional measurements of protein conjugates such as PEGylated proteins and membrane proteins.
13:45 - 14:15 | OMNISEC: More than Size Exclusion Chromatography - Guest speaker: Stéphane Baurin (Plasma Industries)
14:15 - 14:40 | Taylor-Dispersion Analysis (Viscosizer TD) for biophysical characterization of molecules - Markus Epe (Malvern Panalytical)
Viscosizer TD is a biophysical characterization tool that provides unique measurement capabilities for researchers assessing conformational stability, self-association (kD) and solubility of large variety of molecules from small synthetic compounds to target biomolecules in complex solutions. Microcapillary flow methodology also allows complementary relative viscosity measurement, providing high resolution measurements with high reproducibility at low concentration and low viscosity.
14:40 - 15:15 | Introducing Morphologically Directed Raman Spectroscopy for Biopharmaceutical Applications - Anne Virden / Robert Taylor (Malvern Panalytical).
Measuring the size and chemical identity of particles in biotherapeutic formulations is extremely important to ensuring their efficacy and safety.Morphologically Directed Raman Spectroscopy is a unique combination of automated image analysis and RamanSpectroscopy.We will show how this technology can be used to link particle images with Raman spectra to measure particle size and shape, as well as identifying whether particles are protein aggregates, silicon oil or other contaminants.
15:15 - 15:30 | Coffee break
15:30 - 16:00 | Exciting Zetasizer news; MADLS, adaptive correlation, particle concentration - Patrick King (Malvern Panalytical)
16:00 - 17:00 | Parallel practical sessions Zetasizer, new Morphologi4ID - Patrick King / Anne Virden / Robert Taylor (Malvern Panalytical)
17:00 - ... | Closing & drinks - Bruno Devisscher (Sysmex)

Tags: Event location, Belgium, Netherlands, Evenementen

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